Ho pepesetsoa pyrethroids ho ka eketsa kotsi ea lefu la Parkinson ka lebaka la ho sebelisana le liphatsa tsa lefutso ka sesole sa 'mele.
Li-pyrethroids li fumaneha libakeng tse ngata tsa khoebochefo e bolaeang likokoanyana ka lapeng.Leha e le neurotoxic ho likokoanyana, hangata li nkuoa li bolokehile hore li ka kopana le batho ke balaoli ba mmuso.
Phapang ea liphatsa tsa lefutso le ho pepesehela chefo e bolaeang likokoanyana ho bonahala ho susumetsa kotsi ea lefu la Parkinson.Phuputso e ncha e fumana kamano pakeng tsa mabaka ana a mabeli a kotsi, e totobatsang karolo ea karabelo ea 'mele ea ho itšireletsa mafung ho tsoela pele ha mafu.
Liphuputso li amana le sehlopha sachefo e bolaeang likokoanyanae bitsoang pyrethroids, e fumanoang boholong ba chefo e bolaeang likokoanyana ea malapeng 'me e sebelisoa haholo temong ha chefo e meng e felisoa.Leha li-pyrethroids li le neurotoxic ho likokoanyana, ba boholong mmusong hangata ba li nka li bolokehile hore li ka pepesetsoa batho.
Boithuto bona ke ba pele ba ho hokahanya ho pepeseha ha pyrethroid le kotsi ea lefutso bakeng sa lefu la Parkinson le lithuto tse lateloang, ho boletse sengoli-'moho le eena Malu Tansi, Ph.D., motlatsi oa moprofesa oa physiology Sekolong sa Bongaka sa Emory University.
Phapang ea liphatsa tsa lefutso eo sehlopha se se fumaneng e sebakeng se sa ngolisoeng sa liphatsa tsa lefutso tsa MHC II (tse kholo tsa histocompatibility complex class II), sehlopha sa liphatsa tsa lefutso tse laolang sesole sa 'mele.
"Re ne re sa lebella ho fumana sehokelo se itseng sa pyrethroids," ho boletse Tansey.“Hoa tsebahala hore ho pepesehela pyrethroids ka matla ho ka baka ho se sebetse hantle ha ’mele oa ho itšireletsa mafung, ’me limolek’hule tseo li sebetsang ho tsona li ka fumanoa liseleng tsa ’mele tsa ho itšireletsa mafung;Hona joale re hloka ho utloisisa haholoanyane hore na ho pepeseha ha nako e telele ho ama sesole sa 'mele joang 'me ka hona ho ntlafatsa tšebetso ea sona. ”Kotsi ea lefu la Kinson. ”
“Ho se ho ntse ho e-na le bopaki bo matla ba hore ho ruruha ha boko kapa ho sebetsa ho feteletseng ha tsamaiso ea ’mele ea ho itšireletsa mafung ho ka tlatsetsa ho atang ha lefu la Parkinson."Re nahana hore se ka 'nang sa etsahala mona ke hore ho pepeseha ha tikoloho ho ka fetola karabelo ea 'mele ho batho ba bang, ho khothalletsa ho ruruha ho sa feleng bokong."
Bakeng sa thuto, bafuputsi ba Emory ba etelletsoeng ke Tansey le Jeremy Boss, Ph.D., molula-setulo oa Lefapha la Microbiology le Immunology, ba ile ba ikopanya le Stuart Factor, Ph.D., mookameli oa Emory's Comprehensive Parkinson's Disease Center, le Beate Ritz.MD, Univesithi ea California, San Francisco.Ka tšebelisano 'moho le bafuputsi ba bophelo bo botle ba sechaba ba UCLA, Ph.D.Mongoli oa pele oa sehlooho sena ke George T. Kannarkat, MD.
Bafuputsi ba UCLA ba sebelisitse polokelo ea libaka tsa California tse koahelang lilemo tse 30 tsa tšebeliso ea chefo e bolaeang likokoanyana temong.Ba ile ba etsa qeto ea ho pepeseha ho latela sebaka (aterese ea mosebetsi le lehae la motho e mong) empa ba ne ba sa lekanye maemo a chefo e bolaeang likokoanyana 'meleng.Ho nahanoa hore li-pyrethroids li fokotseha ka potlako, haholo-holo ha li hlasetsoe ke letsatsi, ka halofo ea bophelo mobung oa matsatsi ho isa ho libeke.
Har'a batho ba 962 ba tsoang California's Central Valley, mofuta o tloaelehileng oa MHC II o kopantsoeng le ho pepesehela chefo e bolaeang likokoanyana ka pyrethroid ho ile ha eketsa kotsi ea lefu la Parkinson.Mofuta o kotsi ka ho fetisisa oa lefutso (batho ba jereng li-allele tse peli tsa kotsi) o fumanoe ho 21% ea bakuli ba nang le lefu la Parkinson le 16% ea taolo.
Sehlopheng sena, ho pepesehela liphatsa tsa lefutso kapa pyrethroid feela ha hoa ka ha eketsa kotsi ea lefu la Parkinson haholo, empa motsoako o entse joalo.Ha ho bapisoa le karolelano, batho ba neng ba pepesehetse li-pyrethroids 'me ba nkile mofuta o phahameng ka ho fetisisa oa kotsi ea mofuta oa MHC II ba ne ba e-na le kotsi e kholo ka makhetlo a 2.48 ea ho tšoaroa ke lefu la Parkinson ho feta ba nang le ts'oaetso e fokolang le ba nang le mofuta o tlaase oa kotsi ea lefutso.kotsi.Ho pepesehela mefuta e meng ea chefo e bolaeang likokoanyana, joalo ka organophosphates kapa paraquat, ha e eketse kotsi ka tsela e tšoanang.
Lithuto tse kholoanyane tsa liphatsa tsa lefutso, ho kenyelletsa le Factor le bakuli ba hae, li kile tsa amahanya mefuta e fapaneng ea liphatsa tsa lefutso tsa MHC II le lefu la Parkinson.Ho makatsang ke hore mofuta o tšoanang oa liphatsa tsa lefutso o ama kotsi ea lefu la Parkinson ka tsela e fapaneng ho batho ba Caucasians / Europe le batho ba Chaena.Liphatsa tsa lefutso tsa MHC II li fapana haholo pakeng tsa batho ka bomong;ka hona, li phetha karolo ea bohlokoa khethong ea ho fetisetsa litho tsa 'mele.
Liteko tse ling li bontšitse hore liphatsa tsa lefutso tse amanang le lefu la Parkinson li amana le ts'ebetso ea lisele tsa 'mele.Bafuputsi ba fumane hore har'a bakuli ba 81 ba lefu la Parkinson le taolo ea Europe e tsoang Univesithing ea Emory, lisele tsa 'mele tsa ho itšireletsa mafung tse tsoang ho batho ba nang le mefuta e mengata ea liphatsa tsa lefutso tsa MHC II tse tsoang phuputsong ea California li bontšitse limolek'hule tse ngata tsa MHC.
Limolek'hule tsa MHC li theha "antigen presentation" 'me ke matla a susumetsang a etsang hore lisele tsa T li sebetse le ho kenya letsoho tsamaisong ea' mele ea ho itšireletsa mafung.Polelo ea MHC II e eketsoa liseleng tse khutsitseng tsa bakuli ba lefu la Parkinson le taolo e phetseng hantle, empa karabelo e kholo ho phephetso ea 'mele ea ho itšireletsa mafung e bonoa ho bakuli ba lefu la Parkinson ba nang le liphatsa tsa lefutso tse kotsing e kholo;
Bangoli ba phethile ka ho re: "Boitsebiso ba rona bo fana ka maikutlo a hore li-biomarker tsa cellular, joalo ka ts'ebetso ea MHC II, li ka ba molemo ho feta limolek'hule tse qhibilihang ka har'a plasma le cerebrospinal fluid bakeng sa ho tsebahatsa batho ba kotsing ea ho kula kapa ho thaotha bakuli ho nka karolo litekong tsa lithethefatsi tse thibelang mafu."“Teko.”
Boithuto bona bo ne bo tšehetsoa ke Setsi sa Naha sa Mathata a Neurological le Stroke (R01NS072467, 1P50NS071669, F31NS081830), Setsi sa Naha sa Saense ea Bophelo ba Tikoloho (5P01ES016731), Setsi sa Naha sa Kakaretso ea Saense ea Bongaka (GM47310), le Sartain Foundation Lani Michael J. Foxpa Kingson Foundation bakeng sa Lipatlisiso tsa Mafu.
Nako ea poso: Jun-04-2024