Sepheo sa thuto ena ke ho fana ka data kasebolaya dikokoanyanakhanyetso bakeng sa ho etsa liqeto mabapi le mananeo a taolo ea khanyetso naheng ea Togo.
Boemo ba ho ba kotsing ea Anopheles gambiae (SL) ho chefo e bolaeang likokoanyana e sebelisoang bophelong bo botle ba sechaba bo ile ba hlahlojoa ho sebelisoa protocol ea tlhahlobo ea in vitro ea WHO. Li-bioassays tsa ho hanyetsa pyrethroid li entsoe ho latela liprothokholo tsa tlhahlobo ea botlolo ea CDC. Mesebetsi ea enzyme e tlosa chefo e ile ea lekoa ho sebelisoa li-synergists piperonyl butoxide, SSS-phosphorothioate, le ethacrine. Boitsebiso bo ikhethileng ba mefuta le genotyping ea kdr mutation ho Anopheles gambiae SL ho sebelisoa theknoloji ea PCR.
Baahi ba lehae ba Anopheles gambiae sl ba bontšitse monyetla o felletseng oa ho tšoaroa ke pirimiphos-methyl Lomé, Kowie, Aniye le Kpeletutu. Batho ba shoang e ne e le 90% Bayda, e leng se bontšang ho hanyetsa pirimiphos-methyl. Ho hanana le DDT, benzodicarb le propoxur ho tlalehiloe libakeng tsohle. Ho ile ha tlalehoa litekanyetso tse phahameng tsa ho hanyetsa li-pyrethroids, tse nang le oxidase, esterases le glutathione-s-transferases e le li-enzyme tse senyang tse ikarabellang bakeng sa ho hanyetsa, ho latela liteko tsa synergistic. Mefuta e ka sehloohong e ileng ea fumanoa ke Anopheles gambiae (ss) le Anopheles cruzi. Maqhubu a phahameng a kdr L1014F le maqhubu a tlase a kdr L1014S alleles a fumanoe libakeng tsohle.
Phuputso ena e bonts'a tlhokahalo ea lisebelisoa tse eketsehileng tsa ho matlafatsa mehato e teng ea ho laola malaria e thehiloeng ho likokoanyana (IRS le LLIN).
Tšebeliso ea meriana e bolaeang likokoanyana ke karolo ea bohlokoa ea mananeo a taolo ea likokoana-hloko tsa malaria Afrika [1]. Leha ho le joalo, ho hlaha ha ho hanyetsa lihlopha tse ka sehloohong tsa likokoanyana tse sebelisoang kalafo ea marang-rang le ho fafatsa ka masala a ka tlung (IRS) ho hloka hore re nahane hape ka tšebeliso ea lihlahisoa tsena le tsamaiso ea ho hanyetsa vector [2]. Ho hlaha ha ho hanyetsa lithethefatsi ho tlalehiloe linaheng tse sa tšoaneng tsa Afrika Bophirimela ho akarelletsa le Benin, Burkina Faso, Mali [3, 4, 5] haholo-holo Togo [6, 7]. Liphuputso tsa morao-rao li bontšitse hore tšebeliso ea li-synergists le motsoako oa likokoanyana tse bolaeang likokoanyana li eketsa ts'oaetso ea likokoana-hloko tsa malaria libakeng tse nang le khanyetso e phahameng ea pyrethroids [8, 9]. Ho boloka botsitso ba maano a taolo, kopanyo e hlophisitsoeng ea taolo ea khanyetso ho pholisi efe kapa efe ea taolo ea vector e lokela ho nkuoa [2]. Naha efe kapa efe e lokela ho ts'ehetsa ts'ebetsong ea mananeo a taolo ea khanyetso ka ho lemoha khanyetso [10]. Ho ea ka likhothaletso tsa Mokhatlo oa Lefatše oa Bophelo (WHO) [10], taolo ea ho hanyetsa e kenyelletsa ts'ebetsong ea mehato e meraro e kenyelletsang (1) tlhahlobo ea boemo ba ts'oaetso ea likokoana-hloko tsa li-vectors, (2) sebopeho sa matla a ho hanyetsa, le (3) tlhahlobo ea mekhoa ea 'mele, ka tlhokomelo e khethehileng ho katleho ea synergist butoxide piperon. Togo, mohato oa pele, tlhahlobo ea boemo ba ho hlaseloa ke likokoanyana tsa malaria, e etsoa lilemo tse ling le tse ling tse 2-3 libakeng tsa balebeli ba Lenaneo la Naha la Taolo ea Malaria (NMCP). Matla a ho hanyetsa le katleho ea mehato e 'meli ea ho qetela (ke hore, potentiator piperonyl butoxide (PBO), S,S,S-tributyl trisulfate phosphate (DEF), le ethacrynic acid (EA)) ha e e-s'o ithutoe haholo.
Sepheo sa phuputso ena ke ho sebetsana le lintlha tsena tse tharo le ho fa NMCP lintlha tse tšepahalang ho etsa liqeto mabapi le taolo ea khanyetso Togo.
Boithuto bona bo entsoe ho tloha ka Phuptjane ho isa Loetse 2021 libakeng tse khethiloeng tsa balebeli ba NMCP literekeng tse tharo tsa bophelo bo botle ba Togo e ka boroa (setšoantšo sa 1). Libaka tse hlano tsa ho beha leihlo NMCP li khethiloe bakeng sa ho beha leihlo ho ipapisitsoe le libaka tsa tsona (libaka tse fapaneng tsa bohloeki) le litšoaneleho tsa tikoloho (boholo ba li-vector, libaka tsa ho ikatisa tse sa feleng): Lomé, Bayda, Kowie, Anyère le Kpeletoutou (Letlapa la 1).
Phuputso ena e bonts'a hore menang ea sebakeng sa Anopheles gambiae e ka boroa ho Togo e hanyetsana le chefo e bolaeang likokoanyana e mengata e kholo ea bophelo bo botle ba sechaba, ntle le pirimiphos-methyl. Maemo a phahameng a ho hanyetsa pyrethroid a ile a hlokomeloa sebakeng sa thuto, mohlomong se amahanngoa le li-enzyme tse tlosa chefo (oxidase, esterases le glutathione-s-transferases). Phetoho ea kdr L1014F e fumanoe mefuteng e 'meli ea Anopheles gambiae ss le Anopheles kruzi e nang le maqhubu a feto-fetohang empa a le holimo (>0.50), athe phetoho ea kdr L1014S e etsahetse ka nako e tlase haholo 'me e fumanoe feela menoang ea Anopheles cruzi. Li-synergists PBO le EA li khutlisitse ts'oaetso ea pyrethroids le organochlorine ka ho latellana, libakeng tsohle, athe DEF e ile ea eketsa ts'oaetso ea li-carbamates le organophosphates libakeng tsohle ntle le Anye. Lintlha tsena li ka thusa Lenaneo la Naha la Togo la Taolo ea Malaria ho theha maano a sebetsang a ho laola likokoana-hloko.
Nako ea poso: Dec-23-2024