Sethethefatsi se sebetsang sa bongaka ba liphoofolo Colistin Sulfate CAS 1264-72-8

Tlhaloso ea Sehlahisoa

Haholo-holo e na le phello e matla ea antibacterial ho libaktheria tsa gram-negative, 'me libaktheria tse bonolo li kenyelletsa Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella le Vibrio.Proteus, Brucella, Serratia le libaktheria tsohle tsa Gram-positive li ne li hanyetsa sehlahisoa sena.Colistin Sulfatebakeng sa sebolaya-mafu butle, karolo ea mantlha ho membrane ea lisele tsa baktheria, ha e kopana le libaktheria tse nang le kutloelo-bohloko, sebopeho sa eona sa lik'hemik'hale tsa amino ea mahala (Yang) le phosphate ester ea motso oa phosphoric acid ka har'a membrane ea baktheria (e nang le electronegative), e eketsa ho kenella ha membrane. , ho baka sele ea lintho tsa bohlokoa tse kang amino acid, lipina tsa Piao, pyrimidine, K + ea eona.

Akopo

Haholo-holo e sebelisoa ho phekola mafu a mala a bakoang ke Grame-negative bacilli (Escherichia coli, joalo-joalo).E boetse e sebetsa khahlanong le Pseudomonas aeruginosa (sepsis, tšoaetso ea moroto, ho chesa kapa tšoaetso ea maqeba a sithabetsang).

Likaroloana

(1) E na le khanyetso e matla haholo ho libaktheria tsa Gram negative.Haholo-holo, e na le tšitiso e itseng ea tsoelo-pele ho Escherichia coli, Salmonella, le Pseudomonas aeruginosa.

(2) E na le phello ea bactericidal.Ka ho sitisa tšebetso e ikhethileng ea li-membrane tsa lisele, libaktheria lia shoa.

(3) Hoo e ka bang ha ho na mathata a ho hanyetsa lithethefatsi.Ha ho khanyetso ea R-factor e fumanoeng.

(4) E sebetsa ka mokhoa o ts'oanang le lithethefatsi tsa anti Gram positive bacteria.Ha e kopantsoe le zinki bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, joalo-joalo, phello e molemo le ho feta.

(5) Ha ho na mesaletsa.Ha e tsamaisoa ka molomo, e batla e sa amoheloe ke mala, empa nakong ea ente ea intramuscular, pokello ea mali le ho monya li ntle, kahoo ha ho hlokahale hore u tšoenyehe ka masala a lihlahisoa tsa liphoofolo.

(6) Ho khothaletsa kholo ea mehlape le likhoho, le ho thibela le ho laola mafu a tšoaetsanoang a liphoofolo tse ruiloeng le likhoho.