Sethethefatsi se sebetsang sa bongaka ba liphoofolo Colistin Sulfate CAS 1264-72-8

Tlhaloso ea Sehlahisoa

Haholo-holo e na le phello e matla ea antibacterial ho libaktheria tsa gram-negative, 'me libaktheria tse bonolo li kenyelletsa Pseudomonas aeruginosa, Escherichia coli, Enterobacteria, Klebsiella, Salmonella, Shigella, Pasteurella le Vibrio. Proteus, Brucella, Serratia le libaktheria tsohle tsa Gram-positive li ne li hanyetsa sehlahisoa sena.Colistin Sulfatebakeng sa sebolaya ditwatsi butle, karolo e ka sehloohong ho lera baktheria seleng, ha ho kopana le libaktheria nahanela, sebopeho lona lik'hemik'hale tsa mahala amino (Yang) le phosphate ester ea phosphoric acid e motso ka lera baktheria seleng (ka electronegative), eketsa permeability ea lera, etsa hore sele ea lintho tsa bohlokoa tse kang amino acid, Piao lipina, pyrimidine, K + ea eona.

Akopo

Haholo-holo e sebelisoa ho phekola mafu a mala a bakoang ke Grame-negative bacilli (Escherichia coli, joalo-joalo). E boetse e sebetsa khahlanong le Pseudomonas aeruginosa (sepsis, tšoaetso ea moroto, ho chesa kapa tšoaetso ea maqeba a sithabetsang).

Likaroloana

(1) E na le khanyetso e matla haholo ho libaktheria tsa Gram negative. Haholo-holo, e na le tšitiso e itseng ea tsoelo-pele ho Escherichia coli, Salmonella, le Pseudomonas aeruginosa.

(2) E na le phello ea bactericidal. Ka ho sitisa mosebetsi o ikhethileng oa li-membrane tsa lisele, libaktheria lia shoa.

(3) Hoo e ka bang ha ho na mathata a ho hanyetsa lithethefatsi. Ha ho khanyetso ea R-factor e fumanoeng.

(4) E sebetsa ka mokhoa o ts'oanang le lithethefatsi tsa anti Gram positive bacteria. Ha e kopantsoe le zinki bacitracin, flavomycin, sulfonamides, semi synthetic penicillin, gentamicin, joalo-joalo, phello e molemo le ho feta.

(5) Ha ho na mesaletsa. Ha e tsamaisoa ka molomo, e batla e sa amoheloe ke mala, empa nakong ea ente ea intramuscular, pokello ea mali le ho monya li ntle, kahoo ha ho hlokahale hore u tšoenyehe ka masala a lihlahisoa tsa liphoofolo.

(6) Ho khothaletsa kholo ea mehlape le likhoho, le ho thibela le ho laola mafu a tšoaetsanoang a liphoofolo tse ruiloeng le likhoho.